Yukio Fujiwara Selected Research

onionin A

5/2023	Onionin A inhibits small-cell lung cancer proliferation through suppressing STAT3 activation induced by macrophages-derived IL-6 and cell-cell interaction with tumor-associated macrophage.
6/2022	Cyclic sulfur compounds targeting macrophage polarization into M2/protumor phenotype and their anti-tumor effects.
12/2016	Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages.
11/2016	Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells.

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Yukio Fujiwara Research Topics

Disease

58	Neoplasms (Cancer) 05/2024 - 01/2011
11	Atherosclerosis 09/2021 - 04/2007
8	Inflammation (Inflammations) 01/2023 - 06/2007
7	Lymphoma (Lymphomas) 12/2022 - 01/2013
6	Diabetes Complications 04/2016 - 04/2007
5	Breast Neoplasms (Breast Cancer) 06/2023 - 05/2020
5	Ovarian Neoplasms (Ovarian Cancer) 12/2022 - 12/2016
4	Lung Neoplasms (Lung Cancer) 12/2023 - 09/2019
4	Renal Cell Carcinoma (Grawitz Tumor) 07/2023 - 02/2008
4	Hyperlipidemias (Hyperlipidemia) 09/2021 - 11/2007
4	Neoplasm Metastasis (Metastasis) 09/2021 - 06/2013
3	Adenocarcinoma of Lung 12/2023 - 09/2022
3	Carcinogenesis 09/2023 - 01/2021
3	Infections 04/2022 - 04/2014
3	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 01/2011
3	Carcinoma (Carcinomatosis) 10/2021 - 02/2008
3	Osteosarcoma (Osteogenic Sarcoma) 09/2021 - 06/2013
3	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 07/2017 - 08/2016
3	Osteoporosis 01/2014 - 09/2006
2	Hepatoblastoma 02/2024 - 09/2023
2	Bacterial Infections (Bacterial Infection) 04/2022 - 01/2015
2	Rheumatoid Arthritis 01/2020 - 12/2007
2	Proteinuria 01/2020 - 02/2010
2	Septic Shock (Toxic Shock Syndrome) 01/2020 - 08/2011
2	Sarcoma (Soft Tissue Sarcoma) 01/2020 - 06/2013
2	Atherosclerotic Plaque (Atheroma) 01/2018 - 02/2010
2	B-Cell Lymphoma (Lymphoma, B Cell) 07/2017 - 07/2017
2	Hyperglycemia 03/2016 - 06/2007
2	Type 2 Diabetes Mellitus (MODY) 01/2012 - 04/2002
1	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 05/2024
1	Emphysema 12/2023

Drug/Important Bio-Agent (IBA)

10	CholesterolIBA 04/2023 - 02/2008
9	CytokinesIBA 02/2024 - 01/2013
9	LigandsIBA 12/2023 - 11/2016
9	Proteins (Proteins, Gene)FDA Link 01/2023 - 11/2007
8	Advanced Glycation End ProductsIBA 04/2016 - 04/2007
7	Interleukin-6 (Interleukin 6)IBA 05/2023 - 01/2018
7	Apolipoproteins E (ApoE)IBA 09/2021 - 11/2007
6	InterleukinsIBA 02/2024 - 08/2011
5	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 05/2023 - 01/2013
5	Streptozocin (Streptozotocin)FDA Link 04/2016 - 04/2008
4	B7-H1 AntigenIBA 12/2023 - 09/2019
4	Immune Checkpoint InhibitorsIBA 11/2023 - 01/2022
4	onionin AIBA 05/2023 - 11/2016
4	Sulfides (Thioethers)IBA 09/2021 - 01/2012
4	esculeoside AIBA 03/2012 - 11/2007
3	AntibodiesIBA 05/2024 - 09/2022
3	Antineoplastic Agents (Antineoplastics)IBA 02/2024 - 06/2013
3	Messenger RNA (mRNA)IBA 09/2022 - 06/2013
3	NF-kappa B (NF-kB)IBA 01/2022 - 01/2011
3	PyridoxamineIBA 04/2016 - 04/2008
3	corosolic acidIBA 12/2013 - 01/2011
3	Acyl Coenzyme A (Acyl CoA)IBA 03/2012 - 02/2008
3	isoesculeogenin AIBA 03/2012 - 11/2007
2	ErbB Receptors (EGF Receptor)IBA 12/2023 - 09/2019
2	naringinIBA 11/2023 - 01/2018
2	RNA (Ribonucleic Acid)IBA 09/2023 - 04/2014
2	ChemokinesIBA 07/2023 - 09/2022
2	LipidsIBA 04/2023 - 06/2022
2	Macrophage Colony-Stimulating Factor Receptor (Receptor, Macrophage Colony Stimulating Factor)IBA 02/2023 - 07/2011
2	Macrophage Colony-Stimulating FactorIBA 02/2023 - 12/2012
2	Scavenger Receptors (Scavenger Receptor)IBA 12/2022 - 08/2011
2	PD 128042IBA 12/2022 - 06/2022
2	Conditioned Culture MediaIBA 11/2022 - 01/2022
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 11/2022 - 01/2022
2	InterferonsIBA 09/2022 - 08/2011
2	Glucose (Dextrose)FDA LinkGeneric 10/2021 - 01/2012
2	Sterol O-AcyltransferaseIBA 10/2021 - 02/2008
2	TriterpenesIBA 09/2021 - 05/2011
2	Oleanolic AcidIBA 09/2021 - 12/2011
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2021 - 01/2013
2	OsteopontinIBA 09/2021 - 12/2007
2	Glycoproteins (Glycoprotein)IBA 01/2021 - 01/2020
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2020 - 01/2014
2	Concanavalin AIBA 11/2018 - 12/2007
2	ApolipoproteinsIBA 01/2018 - 02/2010
2	MucinsIBA 07/2017 - 11/2016
2	Immunoglobulins (Immunoglobulin)IBA 07/2017 - 11/2016
2	Immune Checkpoint ProteinsIBA 07/2017 - 11/2016
2	AcetoneIBA 01/2017 - 02/2010
2	Cisplatin (Platino)FDA LinkGeneric 11/2016 - 01/2014
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2016 - 08/2011
2	AntioxidantsIBA 01/2015 - 04/2008
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2015 - 09/2012
2	SaponinsIBA 01/2014 - 01/2011
2	Cholesterol Esters (Cholesteryl Esters)IBA 07/2013 - 03/2012
2	Small Interfering RNA (siRNA)IBA 12/2012 - 12/2007
2	Glucagon-Like Peptide 1 (GLP 1)IBA 08/2012 - 01/2012
2	TransferasesIBA 03/2012 - 04/2011
2	N(6)-carboxymethyllysine (carboxymethyllysine)IBA 02/2010 - 06/2007
1	Anaplastic Lymphoma KinaseIBA 05/2024
1	1-phenyl-3,3-dimethyltriazene (PDT)IBA 05/2024
1	AntigensIBA 03/2024
1	Iodothyronine Deiodinase Type IIIBA 12/2023
1	Pancreatic Elastase (Elastase)IBA 12/2023

Therapy/Procedure

30	Therapeutics 05/2024 - 02/2010
9	Immunotherapy 12/2023 - 11/2016
4	Drug Therapy (Chemotherapy) 09/2023 - 12/2013
3	Oral Administration 01/2020 - 02/2010
1	Aftercare (After-Treatment) 05/2024